A study published in the journal Nature Neuroscience reveals that men and women have different perceptions of physical ailments. The research was conducted on laboratory rats found that the cells responsible for pain management are not the same, which would confirm that in humans should be designed pain treatments geared specifically to each sex.
The researchers started with the idea scientifically accepted that pain is transmitted from the site of injury or inflammation of the nervous system by using an immune system cell called microglia. And surprisingly they saw that this only case in male mice. But analyzing the opposite sex found that the T cells are those that appear to be responsible for activating the alarm of pain in female mice. However, experts have not been able to determine exactly how this occurs.
The news portal ABC consulted Jeffrey Mogil of McGill University and Director of the Center for Pain Research Alan Edwards (Canada ), who explained that “it is known that men and women have different sensitivity to pain and that more women than men with chronic pain. But it has always been believed that the wiring of how suffering is processed was the same in both sexes . “
In fact according to the latest National Health Survey of Spain, the pain affects 24.8% of the population aged 15 and over. Of which 3.9% suffer severe pain or extreme (2.1% of men and 5.7% of women). And 20.9% have moderate or mild pain or discomfort. In addition 20 to 25% of respondents have chronic pain. And the vast majority of patients with chronic pain are women.
“The understanding of the pathways of pain and gender differences is absolutely essential to design the next generation drugs targeting more sophisticated pain .Because to the mice are very similar to humans, nervous system especially for basic evolutionary function, such as pain, our results suggest that this information is raised is important in the development of drugs for the pain in humans, “he said Michael Salter of the University of Toronto (Canada), the ABC website.
The information also confirms the relevance of the inclusion of both sexes in any kind of research, whether basic or clinical. In the US, the National Institutes of Health have launched a new policy, similar to that already in force in Canada, which requires the use of animals and cell lines of females in preclinical research. This parity between the sexes, which gradually has been formalized in clinical stages, experts say, can help design therapies truly a la carte, at least according to sex.
( Read the full article ABC)
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