Women can choose from a wide selection of methods of birth control, including oral contraceptives many, but there has never been a similar pill for men. It has not been for lack of trying, because for many years, scientists have attempted to formulate a male pill. a group of researchers has now taken a step toward that goal by deforming some experimental compounds that show promise.
This work has been presented at the 251 National Meeting of the American Chemical Society (ACS , for its acronym in English), which will feature more than 12,500 presentations on a wide range of science topics.
One of the compounds it has been studied as a potential male contraceptive is testosterone. “In certain doses causes infertility explains Jillian Kyzer, a graduate student working on the subject. But at this dose does not work for a maximum of 20% of men and can cause side effects such as weight gain and decreased cholesterol “good”.
to launch a male contraceptive to market must meet several requirements, according to the team leader Kyzer, Gunda I. Georg, Faculty of Pharmacy at the University of Minnesota, United States. for example, should be soluble to be taken orally, work fairly quickly and not decrease libido, besides being safe if taken for decades, but with an impact on the reversible fertility, without remaining negative effects on sperm or embryos.
“That’s a high bar to bring a male market contraceptive,” says Georg. the pharmaceutical companies, including Bristol-Myers Squibb (BMS) have created some experimental male contraceptives, but these also have drawbacks, says Kyzer, as one of the test compounds the company is good at inhibiting fertility, but not very soluble, so it can not be taken orally. “Nobody wants to inject with a needle once a day or once a week for most of his life,” he says.
Another experimental compound Bristol-Myers Squibb can be taken orally, but is not very selective in their cellular targets in the body, meaning that the compound not only interacts with the retinoic acid receptor alpha, which is involved in male fertility, but also with two retinoic acid receptors not they are related to fertility. That failure could cause side effects.
Kyzer and several of his colleagues are creating numerous substances that are similar in chemical structure of the compounds of Bristol-Myers Squibb (BMS). Although the optimal contraceptive for men remains elusive, the team Georg has made some progress, and better understand how the settings of the chemical structure of the test compounds affect cell interactions and substances in the body.
the research team continues to refine the chemical to achieve the best balance of solubility, specificity and stability structures as they aim to design a better male pill. Now they are investigating hybrid compounds incorporating scaffolding and structural characteristics of several other compounds known to interact with retinoic acid receptor.
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